ABSTRACT
This study was designed to compare the plasma level of Endothelin - I and the arterial blood pressure in both normal and streptozotocin induced diabetic rats and to study the effect of insulin treatment on the two tested parameter in normal and diabetic rats. Sixty male rats were used and divided into 5 groups: group [1] [normal rats, served as control A], Group 2 [normal rats treated with insulin for 8 weeks], group 3 [diabetic rats served as control B],Group 4 [diabetic rats treated with insulin for 4 weeks] and Group 5 [diabetic rats treated with insulin for 8 week]. Our results showed that the mean arterial blood pressure was significantly decrease in diabetic rats, while their plasma level of Endothelin- I was higher than the non diabetic rats. Insulin administration to normal and diabetic rats produced significant rise in both tested parameters
Subject(s)
Animals, Laboratory , Endothelin-1/blood , Rats , Blood PressureABSTRACT
This study was designed to investigate the effects of low flow versus high flow on hemodynamic variables, oxygen consumption and metabolic products in the form of lactate and pyruvate in thirty patients undergoing open heart surgery due to rheumatic heart disease. The results showed that hemodynamic parameters [central venous pressure, mean pulmonary artery pressure, pulmonary capillary wedge pressure and systolic and diastolic blood pressure] were not significantly different between the two studied groups in pre-and post bypass. During bypass, the mean arterial blood pressure was significantly higher in high flow rate group than the low flow rate group i.e. blood pressure was flow dependent. In both groups, the systemic vascular resistance was reduced post bypass than pre bypass and the cardiac output was significantly increased during post bypass than pre bypass period and no significant difference could be detected between the two studied groups